We describe a case of desmoplastic variant of ameloblastoma localized in the mandibular anterior portion of the jaw, extending posteriorly in the left side. Desmoplastic variant of ameloblastoma tends to infiltrate between bone trabeculae. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Ameloblastoma patients often experience no symptoms until the tumour is of a larger size. A definite geographic variation has been observed in the frequency of odontogenic tumors and giant cell lesions of the jaws reported from different parts of the world. Whereas enucleation provided a recurrence rate of 21.
Desmoplastic ameloblastoma da is a rare variant of ameloblastoma am. A study of 12 cases, diagnostic cytopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The resulting tumors or cysts are usually not malignant benign but the tissue growth may be aggressive in the involved area. This tumor is more commonly seen in the anterior region of jaws as a mixed radiopaqueradiolucent lesion resembling benign fibroosseous lesions. Desmoplastic variant of ameloblastoma of the maxilla. It is a benign epulisodontogenic tumor that frequently invades bone. Desmoplastic ameloblastoma of the mandible semantic scholar. This is in contrast to classical type of ameloblastoma, which are found in the posterior region of mandible. Clinical features of giant hybrid ameloblastoma of the. Pathology of the desmoplastic ameloblastoma request pdf. Request pdf pathology of the desmoplastic ameloblastoma desmoplastic ameloblastoma is a rare variant of ameloblastoma and only 54 cases have been previously reported in the english literature. Desmoplastic variant of ameloblastoma shows a predilection. Desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant differences in anatomical site. A case report of desmoplastic ameloblastoma marcio bruno amaral 1,3, belini freiremaia 1, marcella rezende serpa 2, ricardo alves mesquita 4 1 professor department of oral and maxillofacial surgery, baleia hospitalcentrare, belo horizonte, mg, brazil.
Desmoplastic ameloblastoma including hybrid lesion of. This lesion occurs with the same frequency in the maxilla and mandible, although the predominant site is the anteriorpremolar site in. The present case deserves special importance because of its unfamiliar appearance, potentially aggressive nature and high chances of misdiagnosis. Desmoplastic ameloblastoma da was included in the world health organization classification of head and neck tumors who2005 as a variant of ameloblastoma with specific clinical, imaging and histological features. Except for the unicystic type, which has a low recurrence rate, no significant differences in the behaviour of these variants have been observed. Ameloblastoma is one of the most common odontogenic neoplasm. Peripheral desmoplastic ameloblastoma in adolescent age. Here, we report a rare case of acanthomatous ameloblastoma present in a young male in the anterior mandibular region crossing the midline, along with an.
Found in near equal frequencies in both maxilla and mandible. Ameloblastoma is a benign lesion with a locally invasive behaviour. Acanthomatous ameloblastoma is considered an aggressive odontogenic tumor characterized by irregular verrucous. Review of literature with a case report vindhya savithri, mahija janardhanan, rakesh suresh, rb vinod kumar department of oral pathology and microbiology, amrita school of dentistry, kochi, india case report address for correspondence. Odontogenic tumors and giant cell lesions of jaws a nine. Desmoplastic variant of ameloblastoma shows a predilection for the maxilla and has a tendency to occur in. Desmoplastic ameloblastoma including hybrid lesion of ameloblastoma.
Histopathology revealed odontogenic epithelium in the form of follicles, typical of solidmulticystic ameloblastoma, with cystic degeneration and squamous metaplasia at places and elsewhere there were odontogenic islands compressed by dense. Reports of new cases of peripheral desmoplastic ameloblastoma are necessary for a better understanding of the origin and behavior of this particular subtype of ameloblastoma. It is defined as a variant of ameloblastoma with specific imaging and histological features. A panoramic radiograph showed an area of radiolucency with a welldefined.
Pdf desmoplastic ameloblastoma is a relatively rare variety of ameloblastoma and only very. A case report on desmoplastic ameloblastoma of anterior. Cone beam computed tomography signs of desmoplastic. Strikingly, smo mutations exhibited a marked preponderance in maxillary. In granular cell ameloblastoma there is marked transformation of the cytoplasm, usually of stellate reticulum like cells, so that it takes. We report a case of desmoplastic ameloblastoma in a 45yearold female with a painless swelling in the left anterior. Desomoplastic ameloblastoma da, a rare histologic variant of solid multicystic ameloblastoma sma was first reported in 1981 3. Although benign, ameloblastoma is a destructive tumour, clinically characterized by expansion of the jaw and local invasion, and shows a high recurrence rate despite treatment with wide surgical removal. For language access assistance, contact the ncats public information officer. Odontoameloblastoma pdf odontoameloblastoma pdf odontoameloblastoma pdf download.
This is a temporary file and hence do not link it from a website, instead link the url of this page if you wish to link the pdf file. Pdf among the ameloblastomas, the desmoplastic variation is rare. Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Resemble a fibroosseous lesion with no obvious ameloblasts whilst dominated by dense collagenous tissue desmoplastic. Odontogenic tumours, ameloblastoma, histopathology. Case report iordanidis, s makos, ch dimitrakopoulos, j kariki, h. The management of mandibular ameloblastoma is currently radical by many teams, to reduce the risk of recurrence. The desmoplastic ameloblastoma da is characterized by specific clinical, imaging, and histological features. Desmoplastic ameloblastoma is an uncommon variant of ameloblastoma with special anatomic distribution, histomorphology and radiographic features that differ from those. Up until now, less than 150 patients have been reported in the literature. Apr 19, 2016 if you have problems viewing pdf files, download the latest version of adobe reader.
This paper describes a case of peripheral ameloblastoma in a 67yearold female affecting the lingual alveolar mucosa of the mandibular 32. The surgical extirpation of ameloblastoma in mandible is challenging. Department of oral and maxillofacial surgery, sibar. The desmoplastic ameloblastoma da is a rare variant of the conventional ameloblastoma. Desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant. A distinctive histological variant of conventional ameloblastoma. A desmoplastie variant of ameloblastoma with osteoplasia in the stroma is reported. Atypical ct findings in plexiform ameloblastoma karandeepsingharora, 1 nageshbinjoo, 2 richamodgil, 1. However, there are a few studies on these lesions, especially giant cell lesions, reported from india. Clinical and histopathological analyses of desmoplastic. Since no primary desmoplastic ameloblastomas were encountered in the present study no further comments can be made on this apparently rare entity. The peripheral desmoplastic ameloblastoma is a rare event, reported in only four cases involving adult patients. Odontogenic tumour, ameloblastoma, ameloblastoma unicystic, ameloblastoma solid, ameloblastoma multicystic.
The desmoplastic ameloblastoma is a variant of ameloblastoma characterized by specific clinical, radiological, and histological features. Clinicopathological characteristics of desmoplastic. Canine acanthomatous ameloblastoma caa is the 4th most common oral tumor in dogs. Ameloblastoma is a rare disorder of the jaw involving abnormal tissue growth. Oral tumors can be difficult to observe, most patients will have presented to their veterinarian with a secondary. The extraosseous location is the peculiar feature of this type of tumour, which is otherwise similar to the classical ameloblastoma. Recurrent desmoplastic ameloblastoma of the maxilla. Pdf ameloblastoma at hospital universiti sains malaysia. Desmoplastic type within the epithelial islands, the cells may assume an organoid configuration it mainly affect the anterior portion of the jaws, specially the maxilla the radiographic appearances may be more suggestive of fibro osseous lesion than an ameloblastoma clear cell ameloblastoma waldrom et al 1993 presence of clear. Among the variants of ameloblastoma, desmoplastic ameloblastoma is a rare and unique entity which is characterized by marked stromal desmoplasia. Desmoplastic ameloblastoma international journal of current.
Key result periapical and panoramic radiographs as well as computer tomography scan showed a mixed lesion with multilocular appearance. Despite the high rates of recurrence, no clinical or radiographic sign of reincidence of the tumor was detected one year later. It has been included in who classification of head and neck tumor who2005 as a variant of ameloblastoma. Acanthomatous epulis peripheral ameloblastoma basal cell carcinoma adamantinoma. We report a case of desmoplastic ameloblastoma in a 45yearold female with a painless swelling in the left anterior maxillary region. Introduction of all swellings of the oral cavity, 9% are odontogenic tumours, and within this group, ameloblastoma accounts for 1% of lesions 14. However, by examining the stromal reaction for collagen type vi in desmoplastic and solidmulticystic stroma, it was concluded that the desmoplastic stroma was not to be interpreted as simple scar tissue but as newly produced connective tissue. Based on the world health organization who classification of head and neck tumours, there are four forms of ameloblastomas. Hybrid desmoplasticfollicular ameloblastoma of the mandible. Furthermore, the airway adequacy is crucial, both during and after mandibulectomy. Besides histological details that combine both conventional ameloblastoma and desmoplastic amelo blastoma, the present case of hybrid ameloblastoma. It accounts for only 4% to % of all ameloblastomas. And this consists of interrupted mandibulectomy often in the course of a diagnosis based on radiological, clinical and epidemiological elements without prior histopathological certainty.
The here presented retrospective analysis investigated the clinicoradiographic features of an overall of 115 dacases, having been reported in literature from 1984 to 2008. Desmoplastic ameloblastoma da is a rare variant of ameloblastoma, and less than 170 patients have been reported in the. Localization of oxytalan fiber, type iii collagen and bmp. Clinical and radiologic behaviour of ameloblastoma in 4 cases. Uncommon variants include desmoplastic, basal cell, clear cell ameloblastoma, keratoameloblastoma, and papilliferous. Mar 18, 2011 desmoplastic ameloblastoma is a rare variant of ameloblastoma.
Desmoplastic ameloblastoma is a rare variant of ameloblastoma and only 54 cases have been previously reported in the english literature. Pdf desmoplastic peripheral ameloblastoma a case report. The location of this lesion, its histology and radiological features differ from those of. The desmoplastic ameloblastoma da is characterized by specific clinical, imaging, and. Coincidently, the present case of desmoplastic ameloblastoma is also seen in a chinese woman from northeast of china. It was initially reported in 1984 and termed ameloblastoma with pronounced desmoplasia by eversole et al. Abstract full text pdf references tables figures at a glance. A case report on desmoplastic ameloblastoma of anterior mandible. This association of desmoplastic ameloblastoma with follicular and acanthomatous patterns, was consistent with the features of socalled hybrid lesion of ameloblastoma fig. Desmoplastic ameloblastoma is a rare variant of benign odontogenic tumors.
In this article we report a case of desmoplastic ameloblastoma in which chronological changes in the early development can be observed on dental radiographs. We use your linkedin profile and activity data to personalize ads and to show you more relevant ads. This tumour presented in the caninepremolar region of the. Recurrent desmoplastic ameloblastoma of the maxilla no typical radiographic features are associated with this variant of ameloblastoma, although a mixed radiolucent radiopaque appearance with illde. A desmoplastic ameloblastoma with features of other histologic types is considered to be a hybrid lesion. Peripheral ameloblastoma, a rare and unusual variant of odontogenic tumour, comprises about 210% of all ameloblastomas. Ameloblastoma, peripheral, desmoplastic, immunohistochemistry. In the recent world health organization classification of odontogenic tumours, desmoplastic ameloblastoma has been characterized as a variant of ameloblastoma, with specific clinical, radiographical, and histological features. Ameloblastoma is a local invasive tumor which originates from remnants of the dental lamina and odontogenic epithelium and it accounts for only 1 % of all oral tumors 1, 2. Biological profile based on 100 cases from the literature and own files. Follicular ameloblastoma was the most common histological type 50 cases, 64. We report ten cases of desmoplastic ameloblastoma of the jaw observed between 1972 and 1998 and discuss the pathogenesis of the tumor. Therefore, in many cases, this rare tumour type is discovered during routine dental xrays before the patient has experienced any symptoms1,5,6 the symptoms of ameloblastoma which are most commonly reported are.
Conventional ameloblastoma has at least six histopathological subtypes, one of which is desmoplastic ameloblastoma da 1. Odontoameloblastoma pdf odontoameloblastoma oa is an extremely rare mixed odontogenic tumor with both epithelial and mesenchymal components. Desmoplastic ameloblastoma differs from other variants of ameloblas toma in that it is more frequently seen in the anterior region of jaw and its mixed radiolucent. This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the french physician louischarles malassez. Half of the desmoplastic ameloblastoma are located in the maxilla, and the vast majority occur in the anterior or premolar portion of jaws. A case of desmoplastic ameloblastoma arising in the. Desmoplastic ameloblastoma mimicking a periapical lesion scielo. The surgical treatment of conventional ameloblastomas has been controversial, however, and reported modalities have included enucleation, curettage, cryotherapy, or radical surgical treatment. Although the present case deviates from the usual desmoplastic variant of ameloblastoma in terms of locus, radiologic. Any supplementary information and source data files are available in the online version of the paper. Desmoplastic ameloblastoma da is a relatively rare histological variant of ameloblastoma with specific clinical, radiological, and histological features. Ameloblastoma is a benign odontogenic tumour of epithelial origin that exhibits a locally aggressive behaviour with a high level of recurrence.
Desmoplastic ameloblastoma is rare, accounting for approximately 4% to % of ameloblastomas. Unicystic ameloblastoma with diverse mural proliferation. Our objective was to describe the clinical and pathological features of desmoplastic ameloblastoma. Ameloblastomas are the second most common odontogenic tumor odontoma is the most common overall, but ameloblastoma is the most common lucent lesion and account for up to onethird of such. Hence, this study was designed to provide a demographic data on the odontogenic tumors and giant cell lesions reported from. A case report on desmoplastic ameloblastoma of anterior mandible by get pdf 2 mb.
A detailed report was given in 1984 by eversole and his coworkers on this variant of ameloblastoma. Desmoplastic ameloblastoma da is an unusual subtype of ameloblastoma characterized by pronounced desmoplastic stroma. Dec 18, 2011 ameloblastoma, desmoplastic type, is a rare lesion for which radiographic images are even less common, and such lesions are sometimes considered to be variant types. Review of literature with a case report article pdf available in journal of oral and maxillofacial pathology 172. Extensive ameloblastoma of the mandible, e journal of teachers association rmc,vol. Among the ameloblastomas, the desmoplastic variation is rare. The mural part of the tumor mass showed follicular and acanthomatous ameloblastoma, which coexisted with desmoplastic ameloblastoma figs. The document provides a descriptive and cross sectional study with prospective data collection. Desmoplastic ameloblastoma da is relatively rare histologic variant of solid multicystic ameloblastoma sma which is characterized by its peculiar histomorphology, that is stromal collagenization which has led to the term ameloblastoma with pronounced desmoplasia hereby present a case of desmoplastic ameloblastoma in a 22 year female. Desmoplastic ameloblastoma a report of two clinical cases. The desmoplastic variant of peripheral ameloblastoma is an extremely rare form of ameloblastoma and presents with very distinct histological. Maxillary lesion are more insidious than mandibular tumors owing to.
This report describes two cases of desmoplastic ameloblastoma in the anterior maxilla of a female patient and the anterior mandible of a male patient, mimicking clinically as an. Pdf desmoplastic ameloblastoma is a relatively rare variety of ameloblastoma and only very few cases have been reported so far. Case report atypical ct findings in plexiform ameloblastoma. A 40yearold male was referred to our hospital complaining of a swelling in the right premolar region of the mandible. Desmoplastic ameloblastoma da is a rare variant of ameloblastoma, and less than patients have been reported in. However, ameloblastoma is unrelated histologically to adamantinoma of the bone, and this terminology should be abandoned to avoid confusion. Ameloblastoma genetic and rare diseases information center. Desmoplastic ameloblastoma da is a rare variant of intraosseous ameloblastoma ia. The surgical reconstruction outcome has been satisfactory up to 12 months post surgery.
Ameloblastomas are tumors arising from the odontogenic. Eight of the ten tumors were located in the anterior region of the jaw. Mar 16, 2016 desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant differences in anatomical site, imaging, and histologic appearance. Ameloblastoma clinical, radiographic and pathologic study of desmoplastic ameloblastoma, j oral maxillofac surg, a case report, j oral maxillfac sorg it has a predilection for the anterior and premolar regions of the mandible and maxilla 2 6. Ameloblastoma nord national organization for rare disorders. Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium ameloblasts, or outside portion, of the teeth during development much more commonly appearing in the lower jaw than the upper jaw. Pathology of the desmoplastic ameloblastoma, journal of oral. There has been no sign of recurrence 7 months after a regular followup and the patient is planned for a long term followup. Desmoplastic ameloblastomaa report of two clinical cases. Desmoplastic variant of ameloblastoma shows a predilection for. Hybrid lesions in which histopathologically conventional ameloblastoma coexists with areas of da are rare. Desmoplastic ameloblastoma da is one of the 6 histopathological subtypes of ameloblastoma. Clinicopathological analysis of histological variants of.
Hybrid variant of desmoplastic ameloblastoma, a rare. Case report rare giant granular cell ameloblastoma. Desmoplastic ameloblastoma is a rare variant of ameloblastoma. It is not clear whether hybrid lesions are due to areas of desmoplastic ameloblastoma transforming into solid ameloblastoma, desmoplastic change occurring in solid.
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